AR Degrader-2

Catalog No.: A81405
AR Degrader
AR Degrader-2 is a molecular glue that targets and promotes the degradation of the androgen receptor (AR) with a DC50 of 0.3-0.5 μM in VCaP cells. This compound is essential for research applications aimed at investigating AR signaling pathways and developing therapeutic strategies for androgen receptor-associated diseases, particularly in prostate cancer. Its potent activity facilitates the study of AR dynamics and may contribute to the advancement of targeted degradation approaches in drug discovery.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Nature Volume 622 Issue 7982 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionAR Degrader-2 is a molecular glue that targets and promotes the degradation of the androgen receptor (AR) with a DC50 of 0.3-0.5 μM in VCaP cells. This compound is essential for research applications aimed at investigating AR signaling pathways and developing therapeutic strategies for androgen receptor-associated diseases, particularly in prostate cancer. Its potent activity facilitates the study of AR dynamics and may contribute to the advancement of targeted degradation approaches in drug discovery.
Product Information
Catalog NumA81405
FormulaC40H49ClN6O4
Molecular Weight713.31
CAS Number3023359-76-1
SMILESCC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)C(N4CCN(CC4)C(/C(C#N)=C/C(C)(C)C)=O)=O)C=C2)=O)[C@H]1OC5=CC(Cl)=C(C=C5)C#N
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