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ARF1 (2-17)

Catalog No.: A77211
PLD Inhibitor
ARF1 (2-17) is a selective inhibitor of phospholipase D (PLD) and phospholipase C-β (PLC-β), targeting both ARF-dependent and ARF-independent signaling pathways. This compound effectively inhibits GTP-γ-S-stimulated PLD activity, thereby playing a crucial role in modulating exocytosis and related cellular processes. Its application in research includes studying lipid signaling and the regulation of membrane traffic in cellular models.
ARF1 (2-17) 143228-35-7 PLD Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionARF1 (2-17) is a selective inhibitor of phospholipase D (PLD) and phospholipase C-β (PLC-β), targeting both ARF-dependent and ARF-independent signaling pathways. This compound effectively inhibits GTP-γ-S-stimulated PLD activity, thereby playing a crucial role in modulating exocytosis and related cellular processes. Its application in research includes studying lipid signaling and the regulation of membrane traffic in cellular models.
Product Information
Catalog NumA77211
FormulaC85H131N21O21
Molecular Weight1783.08
CAS Number143228-35-7
SequenceGly-Asn-Ile-Phe-Ala-Asn-Leu-Phe-Lys-Gly-Leu-Phe-Gly-Lys-Lys-Glu
Sequence shorteningGNIFANLFKGLFGKKE
SMILES[C@@H](CC1=CC=CC=C1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)[C@H](CC)C)=O)=O)C)=O)CC(N)=O)=O)CC(C)C)=O)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(O)=O)=O)CCCCN)=O)CCCCN)=O)=O)=O)CC(C)C)=O)=O)CCCCN)=O
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Metabolism > Phospholipases