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Biological Activity
ARS-1620 is a potent, orally bioavailable covalent inhibitor of KRAS-G12C) and could achieve rapid and sustained in vivo target occupancy to induce tumor regression.
| In vitro | DMSO | 82 mg/mL (190.33 mM) | |
| Water | Insoluble | ||
| Ethanol | 57 mg/mL (132.3 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.21 mL | 116.05 mL | 232.1 mL |
| 0.5 mM | 4.64 mL | 23.21 mL | 46.42 mL |
| 1 mM | 2.32 mL | 11.61 mL | 23.21 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
*The above data is based on the productmolecular weight 430.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16809 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1698055-85-4 |
| Formula | C21H17ClF2N4O2 |
| M. Wt | 430.84 |
| Purity | >98% |
| Synonyms | ARS1620, ARS 1620 |
| SMILES | FC1=CC=CC(O)=C1C2=C(Cl)C=C(C(N3CCN(C(C=C)=O)CC3)=NC=N4)C4=C2F |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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