ARV-771

Catalog No.: A13255

BET degrader

ARV-771

ARV-771 Chemical Structure

CAS NO. 1949837-12-0

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

Availability: In stock

Package Price Qty
1 mg
$144.00
5 mg
$432.00
10 mg
$736.00
50 mg
$2,208.00
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Biological Activity

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
In vitro DMSO 97 mg/mL (98.31 mM)
Water Insoluble
Ethanol 97 mg/mL (98.31 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.14 mL 50.68 mL 101.35 mL
0.5 mM 2.03 mL 10.14 mL 20.27 mL
1 mM 1.01 mL 5.07 mL 10.14 mL
5 mM 0.2 mL 1.01 mL 2.03 mL

*The above data is based on the productmolecular weight 986.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13255
Actions Degrader
CAS No. 1949837-12-0
Formula C49H60ClN9O7S2
M. Wt 986.64
Purity >98%
Synonyms ARV771, ARV 771
SMILES CC(C(C(C1=CC=C(Cl)C=C1)=N[[email protected]@H](CC(NCCOCCCOCC(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]](O)C2)[[email protected]@H]2C(N[[email protected]](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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