ARV-771

Catalog No.: A13255

BET degrader

ARV-771

ARV-771 Chemical Structure

CAS NO. 1949837-12-0

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

Availability: In stock

Package Price Qty
1 mg
$144.00
5 mg
$432.00
10 mg
$736.00
50 mg
$2,208.00
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Biological Activity

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.14 mL 50.68 mL 101.35 mL
0.5 mM 2.03 mL 10.14 mL 20.27 mL
1 mM 1.01 mL 5.07 mL 10.14 mL
5 mM 0.2 mL 1.01 mL 2.03 mL

*The above data is based on the productmolecular weight 986.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13255
Actions Degrader
M. Wt 986.64
Formula C49H60ClN9O7S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1949837-12-0
Synonyms ARV771, ARV 771
SMILES CC(C(C(C1=CC=C(Cl)C=C1)=N[[email protected]@H](CC(NCCOCCCOCC(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]](O)C2)[[email protected]@H]2C(N[[email protected]](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C

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