ASM-IN-2 is a potent inhibitor of acid sphingomyelinase (ASM), exhibiting an IC50 value of 0.87 μM. This compound plays a crucial role in reducing ceramide levels, which is linked to various antidepressant mechanisms of action. Notably, ASM-IN-2 demonstrates significant antidepressant effects in the chronic unpredictable mild stress (CUMS) mouse model, making it an important tool for research in the development of antidepressant therapies.
ASM-IN-2 is a potent inhibitor of acid sphingomyelinase (ASM), exhibiting an IC50 value of 0.87 μM. This compound plays a crucial role in reducing ceramide levels, which is linked to various antidepressant mechanisms of action. Notably, ASM-IN-2 demonstrates significant antidepressant effects in the chronic unpredictable mild stress (CUMS) mouse model, making it an important tool for research in the development of antidepressant therapies.
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