ASP-2205

Catalog No.: A29891
5-HT2C Receptor Agonist
ASP-2205 is a potent agonist of the 5-HT2C receptor, with an EC50 of 0.85 nM for the human receptor and 2.5 nM for the rat receptor. This compound enhances the pudendal nerve-mediated urethral closure reflex, making it a valuable tool for research into therapies for urinary incontinence. ASP-2205 may be instrumental in studying the physiological roles of the 5-HT2C receptor in urogenital function and related disorders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionASP-2205 is a potent agonist of the 5-HT2C receptor, with an EC50 of 0.85 nM for the human receptor and 2.5 nM for the rat receptor. This compound enhances the pudendal nerve-mediated urethral closure reflex, making it a valuable tool for research into therapies for urinary incontinence. ASP-2205 may be instrumental in studying the physiological roles of the 5-HT2C receptor in urogenital function and related disorders.
Product Information
Catalog NumA29891
FormulaC19H28N2O
Molecular Weight300.44
CAS Number1334440-09-3
SMILESCOCCN1C2=C(CCC1)C=C3C(CCNCC3)=C2C4CC4
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