Fig. 1 · Structure
Documents & Downloads
ASP 8477
Cat. No.
A74646
CAS
906737-25-5
FAAH Inhibitor
ASP 8477 is a selective inhibitor of fatty acid amide hydrolase (FAAH), demonstrating IC50 values of 3.99 nM for human FAAH-1, 1.65 nM for the FAAH-1 (P129T) variant, and 57.3 nM for FAAH-2. This compound exhibits central nervous system activity, making it valuable in analgesia research. Its potent inhibition of FAAH positions ASP 8477 as a significant tool for studying pain modulation and endocannabinoid signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 906737-25-5 |
| Applications | FAAH Inhibitor |
| Formula | C18H19N3O3 |
| Molecular Weight | 325.36 |
| SMILES | O=C(N1CCC(C(NC2=CC=CC=C2)=O)CC1)OC3=CC=CN=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.