Biological Activity
AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo
Targets
Target | Value |
---|---|
EGFR | IC50: 0.5nM |
ErbB4 | IC50: 0.8nM |
ErbB2 | IC50: 3.0nM |
EGFR(T790M/L858R) | IC50: 12nM |
FLT1 | IC50: >10μM |
KDR | IC50: >10μM |
PDGFRα | IC50: >10μM |
PDGFRβ | IC50: >10μM |
c-Src | IC50: >10μM |
c-Met | IC50: >10μM |
c-Kit | IC50: >10μM |
IGF-1R | IC50: >10μM |
FGFR1 | IC50: >10μM |
RON | IC50: >10μM |
Abl | IC50: >10μM |
EphA2 | IC50: >10μM |
EphB2 | IC50: >10μM |
Tie-2 | IC50: >10μM |
Syk | IC50: >10μM |
PKCβ2 | IC50: >10μM |
p70S6K | IC50: >10μM |
JAK2 | IC50: >10μM |
Pim2 | IC50: >10μM |
Akt1 | IC50: >10μM |
AuroraA | IC50: >10μM |
CDK2 | IC50: >10μM |
GSK-3β | IC50: >10μM |
In vitro (25°C) | DMSO | 115 mg/mL (185.16 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 0.5% hydroxyethyl cellulose | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 16.1 mL | 80.5 mL | 161 mL |
0.5 mM | 3.22 mL | 16.1 mL | 32.2 mL |
1 mM | 1.61 mL | 8.05 mL | 16.1 mL |
5 mM | 0.32 mL | 1.61 mL | 3.22 mL |
*The above data is based on the productmolecular weight 621.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10062 |
---|---|
Actions | Inhibitor |
CAS No. | 1050500-29-2 |
Formula | C24H18ClFN4O2.C7H8O3S |
M. Wt | 621.1 |
Purity | >98% |
Synonyms | AST6 |
SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
AZD8931 (Sapitinib)
AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling.
BMS-690514
BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kina…
AST-1306
AST-1306, a novel anilino-quinazoline compound, inhibits the enzymatic activities of wild-type epidermal growth factor receptor (EGFR) and E…
AG-490
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhib…
AG-1478 (Tyrphostin AG-1478)
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
Apatinib (YN968D1)
Apatinib (YN968D1) is a tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2, also …
AEE788
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, …
Arry-380 analog
ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and dea…
Keywords:buy AST-6 | AST-6 Supplier | purchase | cost | manufacturer | order | distributor | buy 1050500-29-2| 1050500-29-2 Supplier | purchase 1050500-29-2 | 1050500-29-2 cost | 1050500-29-2 manufacturer | order 1050500-29-2 | 1050500-29-2 distributor