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AST-6

EGFR inhibitor

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Catalog No. A10062

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AST-6 5mg A10062-5
$150.00
AST-6 10mg A10062-10
$240.00
AST-6 25mg A10062-25
$520.00
AST-6 50mg A10062-50
$800.00
AST-6 10mM * 1mL in DMSO A10062-10mM-D
$283.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo

AST-6

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Chemical Information

Catalog Num A10062
Actions Inhibitor
M. Wt 621.1
Formula C24H18ClFN4O2.C7H8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1050500-29-2
Synonyms AST6
SMILES code CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl
Chemical Name N-[4-[[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-6-quinazolinyl]-2-propenamide 4-methylbenzenesulfonate

Biological Activity

Description
 AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo
Targets
Target Value
EGFRIC50: 0.5nM
ErbB4IC50: 0.8nM
ErbB2IC50: 3.0nM
EGFR(T790M/L858R)IC50: 12nM
FLT1IC50: >10μM
KDRIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
c-SrcIC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
IGF-1RIC50: >10μM
FGFR1IC50: >10μM
RONIC50: >10μM
AblIC50: >10μM
EphA2IC50: >10μM
EphB2IC50: >10μM
Tie-2IC50: >10μM
SykIC50: >10μM
PKCβ2IC50: >10μM
p70S6KIC50: >10μM
JAK2IC50: >10μM
Pim2IC50: >10μM
Akt1IC50: >10μM
AuroraAIC50: >10μM
CDK2IC50: >10μM
GSK-3βIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 124 mg/mL (199.65 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.1 mL 80.5 mL 161mL
0.5 mM 3.22 mL 16.1 mL 32.2 mL
1 mM 1.61 mL 8.05 mL 16.1 mL
5 mM 0.32 mL 1.61 mL 3.22 mL

*The above data is based on the productmolecular weight 621.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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