AST-6

Catalog No.: A10062

EGFR inhibitor

AST-6 Chemical Structure

CAS NO. 1050500-29-2

AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$240.00
25 mg
$520.00
50 mg
$800.00
10mM * 1mL in DMSO
$283.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AST-6 is a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, inhibits tumor growth both in vitro and in vivo
Targets
Target Value
EGFRIC50: 0.5nM
ErbB4IC50: 0.8nM
ErbB2IC50: 3.0nM
EGFR(T790M/L858R)IC50: 12nM
FLT1IC50: >10μM
KDRIC50: >10μM
PDGFRαIC50: >10μM
PDGFRβIC50: >10μM
c-SrcIC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
IGF-1RIC50: >10μM
FGFR1IC50: >10μM
RONIC50: >10μM
AblIC50: >10μM
EphA2IC50: >10μM
EphB2IC50: >10μM
Tie-2IC50: >10μM
SykIC50: >10μM
PKCβ2IC50: >10μM
p70S6KIC50: >10μM
JAK2IC50: >10μM
Pim2IC50: >10μM
Akt1IC50: >10μM
AuroraAIC50: >10μM
CDK2IC50: >10μM
GSK-3βIC50: >10μM
In vitro (25°C) DMSO 124 mg/mL (199.65 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% hydroxyethyl cellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.1 mL 80.5 mL 161 mL
0.5 mM 3.22 mL 16.1 mL 32.2 mL
1 mM 1.61 mL 8.05 mL 16.1 mL
5 mM 0.32 mL 1.61 mL 3.22 mL

*The above data is based on the productmolecular weight 621.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10062
Actions Inhibitor
M. Wt 621.1
Formula C24H18ClFN4O2.C7H8O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1050500-29-2
Synonyms AST6
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

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