Fig. 1 · Structure
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AT 1001 (free base)
nAChR Antagonist
AT 1001 is a selective antagonist of the α3β4 nicotinic acetylcholine receptor (nAChR), with a high affinity characterized by a Ki value of 2.64 nM. This compound effectively reverses inward currents triggered by Epibatidine in HEK cells expressing α3β4 nAChR. AT 1001 demonstrates dose-dependent inhibition of nicotine self-administration in rat models, while sparing food-reinforced responding, making it a valuable tool in nicotine addiction and smoking cessation therapy research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1314801-63-2 |
| Applications | nAChR Antagonist |
| Formula | C15H21BrN2 |
| Molecular Weight | 309.24 |
| SMILES | BrC(C=CC=C1)=C1N[C@H]2C[C@@H]3N(C)[C@@H](CCC3)C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.