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AT7519 HCl

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CDK inhibitor

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Catalog No. A11313

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT7519 HCl 5mg A11313-5

Regular Price: €76.00

Special Price: €68.40

AT7519 HCl 10mg A11313-10

Regular Price: €114.00

Special Price: €102.60

AT7519 HCl 25mg A11313-25

Regular Price: €228.00

Special Price: €205.20

AT7519 HCl 50mg A11313-50

Regular Price: €418.00

Special Price: €376.20

AT7519 HCl 10mM * 1mL in DMSO A11313-10mM-D

Regular Price: €90.25

Special Price: €81.23

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

AT7519 HCl

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Chemical Information

Catalog Num A11313
Actions Inhibitor
M. Wt 418.7
Formula C16H17Cl2N5O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 902135-91-5
Synonyms AT 7519, AT-7519
SMILES C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl

Biological Activity

Description
 AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
Targets
Target Value
CDK9/CyclinTIC50: <10nM
CDK5/p35IC50: 13nM
CDK2/CyclinAIC50: 47nM
GSK-3βIC50: 89nM
CDK4/CyclinD1IC50: 100nM
CDK6/CyclinD3IC50: 170nM
CDK1/CyclinBIC50: 210nM
CDK3/CyclinEIC50: 360nM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
TrkBIC50: >1μM
JAK2IC50: >1μM
CDK7/CyclinH/MAT1IC50: 2.4μM
SAPK2A(p38α)IC50: >10μM
p70S6KIC50: >10μM
PDGFRIC50: >10μM
PDK-1IC50: >10μM
PKBβIC50: >10μM
VEGFR1IC50: >10μM
AuroraAIC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
Chk1IC50: >10μM
EGFRIC50: >10μM
FGFR3IC50: >10μM
IRIC50: >10μM
JNK2IC50: >10μM
MAPK1IC50: >10μM
MEK1IC50: >10μM
MetIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 10 mg/mL (26.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.88 mL 119.42 mL 238.83mL
0.5 mM 4.78 mL 23.88 mL 47.77 mL
1 mM 2.39 mL 11.94 mL 23.88 mL
5 mM 0.48 mL 2.39 mL 4.78 mL

*The above data is based on the productmolecular weight 418.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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