Biological Activity
AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
Targets
Target | Value |
---|---|
CDK9/CyclinT | IC50: <10nM |
CDK5/p35 | IC50: 13nM |
CDK2/CyclinA | IC50: 47nM |
GSK-3β | IC50: 89nM |
CDK4/CyclinD1 | IC50: 100nM |
CDK6/CyclinD3 | IC50: 170nM |
CDK1/CyclinB | IC50: 210nM |
CDK3/CyclinE | IC50: 360nM |
PI3Kβ | IC50: >1μM |
PLK3 | IC50: >1μM |
RET | IC50: >1μM |
SGK | IC50: >1μM |
TrkB | IC50: >1μM |
JAK2 | IC50: >1μM |
CDK7/CyclinH/MAT1 | IC50: 2.4μM |
SAPK2A(p38α) | IC50: >10μM |
p70S6K | IC50: >10μM |
PDGFR | IC50: >10μM |
PDK-1 | IC50: >10μM |
PKBβ | IC50: >10μM |
VEGFR1 | IC50: >10μM |
AuroraA | IC50: >10μM |
c-Abl | IC50: >10μM |
c-Src | IC50: >10μM |
Chk1 | IC50: >10μM |
EGFR | IC50: >10μM |
FGFR3 | IC50: >10μM |
IR | IC50: >10μM |
JNK2 | IC50: >10μM |
MAPK1 | IC50: >10μM |
MEK1 | IC50: >10μM |
Met | IC50: >10μM |
In vitro (25°C) | DMSO | Warmed: 49 mg/mL (117.03 mM) | |
Water | Warmed: 40 mg/mL (95.53 mM) | ||
Ethanol | Warmed: 26 mg/mL (62.09 mM) | ||
In vivo | Saline | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.88 mL | 119.42 mL | 238.83 mL |
0.5 mM | 4.78 mL | 23.88 mL | 47.77 mL |
1 mM | 2.39 mL | 11.94 mL | 23.88 mL |
5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
*The above data is based on the productmolecular weight 418.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11313 |
---|---|
Actions | Inhibitor |
CAS No. | 902135-91-5 |
Formula | C16H17Cl2N5O2.HCl |
M. Wt | 418.7 |
Purity | >98% |
Synonyms | AT 7519, AT-7519 |
SMILES | C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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