ATC-324 is a bivalent androgen receptor (AR) degrader that utilizes the AUTOTAC (AUTOphagy-TArgeting Chimera) technology to promote targeted protein degradation. It facilitates the assembly of an AR/p62 complex, triggering autophagy-mediated lysosomal degradation of the AR, which results in reduced nuclear AR levels and diminished expression of AR and AR-v7 target genes. Additionally, ATC-324 effectively degrades various common AR mutants associated with prostate cancer. This compound consists of the target-binding ligand Enzalutamide and the p62 autophagy-targeting ligand YT 6-2 analog-1, interconnected by a PEG-based linker for enhanced cellular uptake.
ATC-324 is a bivalent androgen receptor (AR) degrader that utilizes the AUTOTAC (AUTOphagy-TArgeting Chimera) technology to promote targeted protein degradation. It facilitates the assembly of an AR/p62 complex, triggering autophagy-mediated lysosomal degradation of the AR, which results in reduced nuclear AR levels and diminished expression of AR and AR-v7 target genes. Additionally, ATC-324 effectively degrades various common AR mutants associated with prostate cancer. This compound consists of the target-binding ligand Enzalutamide and the p62 autophagy-targeting ligand YT 6-2 analog-1, interconnected by a PEG-based linker for enhanced cellular uptake.
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