Atuzabrutinib

Catalog No.: A34404
Btk Inhibtior
Atuzabrutinib is a selective reversible inhibitor of Bruton's tyrosine kinase (Btk), which plays a crucial role in B-cell receptor signaling. This compound demonstrates significant inhibition of neutrophil recruitment through the modulation of macrophage antigen-1 signaling pathways. Atuzabrutinib is primarily utilized in research focused on B-cell mediated autoimmunity, chronic inflammatory diseases, and various malignancies. Its targeted action on Btk makes it valuable in studying therapeutics aimed at B-cell related disorders.
Grouped product items
Size Price Stock Qty
1mg
$55.00
In stock
5mg
$130.00
In stock
10mg
$210.00
In stock
25mg
$335.00
In stock
50mg
$465.00
In stock
100mg
$630.00
In stock
200mg
$840.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAtuzabrutinib is a selective reversible inhibitor of Bruton's tyrosine kinase (Btk), which plays a crucial role in B-cell receptor signaling. This compound demonstrates significant inhibition of neutrophil recruitment through the modulation of macrophage antigen-1 signaling pathways. Atuzabrutinib is primarily utilized in research focused on B-cell mediated autoimmunity, chronic inflammatory diseases, and various malignancies. Its targeted action on Btk makes it valuable in studying therapeutics aimed at B-cell related disorders.
Product Information
Catalog NumA34404
FormulaC30H30FN7O2
Molecular Weight539.60
CAS Number1581714-49-9
SMILESNC1=C2C(N([C@H]3CN(CCC3)C(/C(C#N)=C/C(C)(C)C)=O)N=C2C4=C(C=C(C=C4)OC5=CC=CC=C5)F)=NC=N1
SynonymsSAR 444727; PRN473
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