AU-1421 is a potassium ion (K⁺) site-directed regulator that selectively interacts with various cation transport ATPases. This compound distinguishes between two K⁺-sensitive phosphorylation intermediate (E2P) states, accelerating hydrolysis in non-K⁺ transport ATPases such as sarcoplasmic reticulum Ca²⁺-ATPase, while inhibiting hydrolysis and stabilizing the phosphorylated state in K⁺ transport ATPases, including gastric mucosa H⁺/K⁺-ATPase and renal Na⁺/K⁺-ATPase. AU-1421 is valuable for investigating the mechanistic pathways of potassium ion pumps in cellular processes.
AU-1421 is a potassium ion (K⁺) site-directed regulator that selectively interacts with various cation transport ATPases. This compound distinguishes between two K⁺-sensitive phosphorylation intermediate (E2P) states, accelerating hydrolysis in non-K⁺ transport ATPases such as sarcoplasmic reticulum Ca²⁺-ATPase, while inhibiting hydrolysis and stabilizing the phosphorylated state in K⁺ transport ATPases, including gastric mucosa H⁺/K⁺-ATPase and renal Na⁺/K⁺-ATPase. AU-1421 is valuable for investigating the mechanistic pathways of potassium ion pumps in cellular processes.
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