AUTAC1 is an autophagy-mediated degrader specifically targeting MetAP2. This compound features a degradation tag and a warhead that ensures target specificity. The structure of AUTAC1 includes p-Fluorobenzyl Guanine (FBnG) and a Fumagillol moiety, with Fumagillol covalently binding to MetAP2. This compound is valuable for research applications focused on the regulation of protein degradation pathways and the study of MetAP2's role in cellular processes.
AUTAC1 is an autophagy-mediated degrader specifically targeting MetAP2. This compound features a degradation tag and a warhead that ensures target specificity. The structure of AUTAC1 includes p-Fluorobenzyl Guanine (FBnG) and a Fumagillol moiety, with Fumagillol covalently binding to MetAP2. This compound is valuable for research applications focused on the regulation of protein degradation pathways and the study of MetAP2's role in cellular processes.
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