AUY 954 hydrochloride is a potent and selective agonist of the sphingosine-1-phosphate (S1P(1)) receptor, exhibiting significant immunomodulatory properties. It induces a notable and reversible decrease in circulating lymphocytes following oral administration. In preclinical studies, AUY 954 hydrochloride has shown efficacy in prolonging cardiac allograft survival in conjunction with RAD001, as well as effectively preventing experimental autoimmune neuritis in rat models. This compound holds promising therapeutic potential for various autoimmune conditions.
AUY 954 hydrochloride is a potent and selective agonist of the sphingosine-1-phosphate (S1P(1)) receptor, exhibiting significant immunomodulatory properties. It induces a notable and reversible decrease in circulating lymphocytes following oral administration. In preclinical studies, AUY 954 hydrochloride has shown efficacy in prolonging cardiac allograft survival in conjunction with RAD001, as well as effectively preventing experimental autoimmune neuritis in rat models. This compound holds promising therapeutic potential for various autoimmune conditions.
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