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Avasimibe (CI-1011)

Catalog No.: A10102

CYP17 inhibitor

Avasimibe (CI-1011)

Avasimibe (CI-1011) Chemical Structure

CAS NO. 166518-60-1

Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.

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10 mg

Regular Price: $50.00

Special Price $40.00

50 mg

Regular Price: $180.00

Special Price $144.00

100 mg

Regular Price: $320.00

Special Price $256.00

200 mg

Regular Price: $520.00

Special Price $416.00

10mM * 1mL in DMSO

Regular Price: $84.00

Special Price $67.20

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yuyan Zhu, .et al. Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake, Metabolism, 2021, Oct;123:154861 PMID: 34371065

Biological Activity

Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
Targets
CYP2C9 ACAT CYP1A2 CYP2C19
2.9 μM3.3 μM13.9 μM26.5 μM
In vitro (25°C) DMSO 96 mg/mL (191.34 mM)
Water Insoluble
Ethanol 8 mg/mL (15.94 mM)
In vivo 2% DMSO+corn oil 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.93 mL 99.66 mL 199.32 mL
0.5 mM 3.99 mL 19.93 mL 39.86 mL
1 mM 1.99 mL 9.97 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL

*The above data is based on the productmolecular weight 501.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10102
Actions Inhibitor
CAS No. 166518-60-1
Formula C29H43NO4S
M. Wt 501.7
Purity >98%
Synonyms CI-1011, CI1011, PD 148515
SMILES CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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