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- Yuyan Zhu, .et al. Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake, Metabolism, 2021, Oct;123:154861 PMID: 34371065
Biological Activity
Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor.
Targets
| CYP2C9 | ACAT | CYP1A2 | CYP2C19 | |
| 2.9 μM | 3.3 μM | 13.9 μM | 26.5 μM |
| In vitro (25°C) | DMSO | 96 mg/mL (191.34 mM) | |
| Water | Insoluble | ||
| Ethanol | 8 mg/mL (15.94 mM) | ||
| In vivo | 2% DMSO+corn oil | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.93 mL | 99.66 mL | 199.32 mL |
| 0.5 mM | 3.99 mL | 19.93 mL | 39.86 mL |
| 1 mM | 1.99 mL | 9.97 mL | 19.93 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.99 mL |
*The above data is based on the productmolecular weight 501.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10102 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 166518-60-1 |
| Formula | C29H43NO4S |
| M. Wt | 501.7 |
| Purity | >98% |
| Synonyms | CI-1011, CI1011, PD 148515 |
| SMILES | CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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