Avitinib (AC0010)

Catalog No.: A16826

irreversible EGFR inhibitor

Avitinib (AC0010)

Avitinib (AC0010) Chemical Structure

CAS NO. 1557267-42-1

Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$400.00
100 mg
$600.00
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Biological Activity

Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.51 mL 102.56 mL 205.12 mL
0.5 mM 4.1 mL 20.51 mL 41.02 mL
1 mM 2.05 mL 10.26 mL 20.51 mL
5 mM 0.41 mL 2.05 mL 4.1 mL

*The above data is based on the productmolecular weight 487.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16826
Actions Inhibitor
M. Wt 487.53
Formula C26H26FN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1557267-42-1
Synonyms AC-0010, AC 0010, Abivertinib
SMILES C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O

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