AWD 12-281 is a potent and selective inhibitor of phosphodiesterase 4 (PDE4), with an IC50 of 9.7 nM. This compound demonstrates significant anti-inflammatory activity and is primarily utilized in research focused on allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Its oral bioavailability facilitates in vivo studies of PDE4 modulation in various inflammatory diseases.
AWD 12-281 is a potent and selective inhibitor of phosphodiesterase 4 (PDE4), with an IC50 of 9.7 nM. This compound demonstrates significant anti-inflammatory activity and is primarily utilized in research focused on allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. Its oral bioavailability facilitates in vivo studies of PDE4 modulation in various inflammatory diseases.
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