Axitinib-13C,d3 is a stable isotope-labeled version of the multi-targeted tyrosine kinase inhibitor Axitinib, incorporating both carbon-13 and deuterium isotopes. Axitinib exhibits potent inhibitory activity against several receptor tyrosine kinases, with IC50 values of 0.1 nM for VEGFR1, 0.2 nM for VEGFR2, 0.1-0.3 nM for VEGFR3, and 1.6 nM for PDGFRβ. This reagent is particularly valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in drug metabolism and interaction research.
Axitinib-13C,d3 is a stable isotope-labeled version of the multi-targeted tyrosine kinase inhibitor Axitinib, incorporating both carbon-13 and deuterium isotopes. Axitinib exhibits potent inhibitory activity against several receptor tyrosine kinases, with IC50 values of 0.1 nM for VEGFR1, 0.2 nM for VEGFR2, 0.1-0.3 nM for VEGFR3, and 1.6 nM for PDGFRβ. This reagent is particularly valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in drug metabolism and interaction research.
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