Fig. 1 · Structure
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Axitinib-13C,d3
Stable Isotope
Axitinib-13C,d3 is a stable isotope-labeled version of the multi-targeted tyrosine kinase inhibitor Axitinib, incorporating both carbon-13 and deuterium isotopes. Axitinib exhibits potent inhibitory activity against several receptor tyrosine kinases, with IC50 values of 0.1 nM for VEGFR1, 0.2 nM for VEGFR2, 0.1-0.3 nM for VEGFR3, and 1.6 nM for PDGFRβ. This reagent is particularly valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in drug metabolism and interaction research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1261432-00-1 |
| Applications | Stable Isotope |
| Formula | C2113CH15D3N4OS |
| Molecular Weight | 390.48 |
| Synonyms | AG-013736-13C，d3 |
| SMILES | [2H][13C]([2H])([2H])NC(C(C=CC=C1)=C1SC2=CC=C3C(/C=C/C4=CC=CC=N4)=NNC3=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.