AZ-5104-d2 is a deuterium-labeled derivative of AZ-5104, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates potent inhibitory activity with IC50 values of 1 nM for EGFRL858R/T790M, 6 nM for EGFRL858R, 1 nM for EGFRL861Q, 25 nM for EGFR, and 7 nM for ErbB4. This stable isotope variant is valuable for applications in pharmacokinetics and metabolic studies, providing insights into EGFR-mediated signaling pathways and therapeutic interventions.
AZ-5104-d2 is a deuterium-labeled derivative of AZ-5104, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates potent inhibitory activity with IC50 values of 1 nM for EGFRL858R/T790M, 6 nM for EGFRL858R, 1 nM for EGFRL861Q, 25 nM for EGFR, and 7 nM for ErbB4. This stable isotope variant is valuable for applications in pharmacokinetics and metabolic studies, providing insights into EGFR-mediated signaling pathways and therapeutic interventions.
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