AZ5104

Catalog No.: A15516

EGFR inhibitor

AZ5104

AZ5104 Chemical Structure

CAS NO. 1421373-98-9

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.

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Package Price Qty
10 mg
$80.00
25 mg
$160.00
50 mg
$278.00
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Biological Activity

AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Targets
Target Value
EGFR(L858R/T790M)IC50: <1nM
EGFR(L861Q)IC50: 1nM
EGFR(L858R)IC50: 6nM
ErbB4IC50: 7nM
EGFR(wildtype)IC50: 25nM
ACK1IC50: 27nM
BLKIC50: 27nM
BRKIC50: 45nM
MNK2IC50: 62nM
IGF1-RIC50: 78nM
ALKIC50: 97nM
TECIC50: 118nM
FESIC50: 127nM
InsRIC50: 127nM
FLT3IC50: 129nM
BTKIC50: 132nM
FAKIC50: 136nM
MLK1IC50: 141nM
FLT4IC50: 142nM
PYK2IC50: 284nM
IRRIC50: 423nM
TxkIC50: 426nM
BMXIC50: 505nM
ITKIC50: 925nM
JAK3IC50: 1358nM
In vitro (25°C) DMSO 90 mg/mL (185.34 mM)
Water Insoluble
Ethanol Warmed: 21 mg/mL (43.24 mM)
In vivo 1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.59 mL 102.97 mL 205.94 mL
0.5 mM 4.12 mL 20.59 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.59 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15516
Actions Inhibitor
CAS No. 1421373-98-9
Formula C27H31N7O2
M. Wt 485.58
Solubility DMSO
Purity >98%
Synonyms AZ-5104, AZ 5104
SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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