Biological Activity
AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
Targets
C-Raf-1 (Cell-free assay) | B-Raf (V600E) (Cell-free assay) | B-Raf (Cell-free assay) | ||
29 nM | 34 nM | 105 nM |
In vitro (25°C) | DMSO | 80 mg/mL (177.17 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.15 mL | 110.74 mL | 221.48 mL |
0.5 mM | 4.43 mL | 22.15 mL | 44.3 mL |
1 mM | 2.21 mL | 11.07 mL | 22.15 mL |
5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11063 |
---|---|
Actions | Inhibitor |
CAS No. | 878739-06-1 |
Formula | C27H25N5O2 |
M. Wt | 451.5 |
Purity | >98% |
Synonyms | AZ-628 |
SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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