AZ628

Catalog No.: A11063

Raf inhibitor

AZ628 Chemical Structure

CAS NO. 878739-06-1

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

Regular Price: $110.00

Special Price $88.00

25 mg

Regular Price: $220.00

Special Price $176.00

50 mg

Regular Price: $360.00

Special Price $288.00

10mM * 1mL in DMSO
$75.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AZ628 is a RAF inhibitor with IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF.
Targets
C-Raf-1 (Cell-free assay) B-Raf (V600E) (Cell-free assay) B-Raf (Cell-free assay)
29 nM34 nM105 nM
In vitro (25°C) DMSO 90 mg/mL (199.32 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.15 mL 110.74 mL 221.48 mL
0.5 mM 4.43 mL 22.15 mL 44.3 mL
1 mM 2.21 mL 11.07 mL 22.15 mL
5 mM 0.44 mL 2.21 mL 4.43 mL

*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11063
Actions Inhibitor
M. Wt 451.5
Formula C27H25N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 878739-06-1
Synonyms AZ-628
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C

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