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AZD 9272

mGluR5 antagonist

AZD 9272 is a brain penetrant mGluR5 antagonist.

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Biological Activity

Target & Activity

Target	Activity	Value
mGluR5

Cellular Effect

Cell Line	Activity	Value	Description	Reference
HEK293	IC50	2.6 nM	Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay	[PMID: 23046966]
HEK293	IC50	26 nM	Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated IP accumulation incubated for 10 mins prior to glutamate challenge measured 30 mins post glutamate challen	[PMID: 23046966]
HEK293	IC50	7.6 nM	Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellular Ca2+ level after 30 mins by FLIPR assay	[PMID: 23046966]

Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	327056-26-8
Applications	mGluR5 antagonist
Formula	C₁₄H₆F₂N₄O
Molecular Weight	284.22
SMILES	N#CC1=CC(F)=CC(C2=NC(C3=CC=C(F)C=N3)=NO2)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.