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$0.00 - Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839
Biological Activity
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
Targets
| L858R/T790M EGFR (LoVo cells) | Exon 19 deletion EGFR (LoVo cells) | WT EGFR (LoVo cells) | ||
| 11.44 nM | 12.92 nM | 493.8 nM |
| In vitro | DMSO | 99 mg/mL heating (198.15 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 43 mg/mL heating (86.06 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.02 mL | 100.08 mL | 200.16 mL |
| 0.5 mM | 4 mL | 20.02 mL | 40.03 mL |
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13681 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 499.61 |
| Formula | C28H33N7O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1421373-65-0 |
| Synonyms | AZD 9291, AZD9291 |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC |
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