AZD-9291 (Osimertinib)

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
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Product Name Price Stock Qty
AZD-9291 5mg
$50.00
In stock
AZD-9291 10mg
$70.00
In stock
AZD-9291 50mg
$95.00
In stock
AZD-9291 10mM * 1mL in DMSO
$55.00
In stock
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Adooq Products cited in reputable paper
Adooq's AZD-9291 (Osimertinib) has been cited by 1 publications
  • Liu YN, .et al. , Int J Cancer, 2019, Jun 4 PMID: 31162839
  • Biological Activity
    Discription AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
    Targets
    Target Value
    Product Information
    Catalog Num A13681
    Formula C28H33N7O2
    Molecular Weight 499.61
    CAS Number 1421373-65-0
    SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
    Synonyms AZD 9291, AZD9291
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 90 mg/mL (180.14 mM)
    Water Insoluble
    Ethanol Warmed: 39 mg/mL (78.05 mM)
    In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 7.1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.02 mL 100.08 mL 200.16 mL
    0.5 mM 4 mL 20.02 mL 40.03 mL
    1 mM 2 mL 10.01 mL 20.02 mL
    5 mM 0.4 mL 2 mL 4 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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