Total item
Cart Subtotal
$0.00 Biological Activity
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
Targets
| L858R/T790M EGFR (LoVo cells) | Exon 19 deletion EGFR (LoVo cells) | WT EGFR (LoVo cells) | ||
| 11.44 nM | 12.92 nM | 493.8 nM |
| In vitro | DMSO | 99 mg/mL heating (198.15 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 43 mg/mL heating (86.06 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.02 mL | 100.08 mL | 200.16 mL |
| 0.5 mM | 4 mL | 20.02 mL | 40.03 mL |
| 1 mM | 2 mL | 10.01 mL | 20.02 mL |
| 5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13681 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 499.61 |
| Formula | C28H33N7O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1421373-65-0 |
| Synonyms | AZD 9291, AZD9291 |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
PF299804 (Dacomitinib, PF299)
PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HE…
CL-387785 (EKI-785)
CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a f…
AG-1478 (Tyrphostin AG-1478)
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
SU-5402
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor…
AV-412
AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth facto…
AZD3759
AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as we…
Gefitinib (Iressa)
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells.
Keywords:buy AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) Supplier | purchase AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) cost | AZD-9291 (Osimertinib) manufacturer | order AZD-9291 (Osimertinib) | AZD-9291 (Osimertinib) distributor | buy 1421373-65-0| 1421373-65-0 Supplier | purchase 1421373-65-0 | 1421373-65-0 cost | 1421373-65-0 manufacturer | order 1421373-65-0 | 1421373-65-0 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.