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AZD-9291 (Osimertinib)


EGFR inhibitor

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Catalog No. A13681

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD-9291 5mg A13681-5

Regular Price: $50.00

Special Price: $45.00

AZD-9291 10mg A13681-10

Regular Price: $70.00

Special Price: $63.00

AZD-9291 25mg A13681-25

Regular Price: $100.00

Special Price: $90.00

AZD-9291 50mg A13681-50

Regular Price: $120.00

Special Price: $108.00

AZD-9291 10mM * 1mL in DMSO A13681-10mM-D

Regular Price: $55.00

Special Price: $49.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

AZD-9291 (Osimertinib)

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Chemical Information

Catalog Num A13681
Actions Inhibitor
M. Wt 499.61
Formula C28H33N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1421373-65-0
Synonyms AZD 9291, AZD9291
Chemical Name N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Biological Activity

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
L858R/T790M EGFR (LoVo cells) Exon 19 deletion EGFR (LoVo cells) WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM


Solubility (25°C)* In vitro DMSO 99 mg/mL heating (198.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol 43 mg/mL heating (86.06 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.08 mL 200.16mL
0.5 mM 4 mL 20.02 mL 40.03 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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