AZD-9291 (Osimertinib)

Catalog No.: A13681

EGFR inhibitor

AZD-9291 (Osimertinib)

AZD-9291 (Osimertinib) Chemical Structure

CAS NO. 1421373-65-0

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$70.00
50 mg
$95.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839

Biological Activity

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.
Targets
L858R/T790M EGFR (LoVo cells) Exon 19 deletion EGFR (LoVo cells) WT EGFR (LoVo cells)
11.44 nM12.92 nM493.8 nM
In vitro (25°C) DMSO Warmed: 90 mg/mL (180.14 mM)
Water Insoluble
Ethanol Warmed: 39 mg/mL (78.05 mM)
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 7.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.02 mL 100.08 mL 200.16 mL
0.5 mM 4 mL 20.02 mL 40.03 mL
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13681
Actions Inhibitor
CAS No. 1421373-65-0
Formula C28H33N7O2
M. Wt 499.61
Purity >98%
Synonyms AZD 9291, AZD9291
SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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