AZD-9291 (Osimertinib)

Name: AZD-9291 (Osimertinib)
Brand: Adooq Bioscience
SKU: A13681
Rating: 100 (1 reviews)

Catalog No.: A13681

EGFR inhibitor

Product Citations (1)

AZD-9291 (Osimertinib) Chemical Structure

CAS NO. 1421373-65-0

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

Availability: In stock

Package	Price	Qty
5 mg	$50.00
10 mg	$70.00
50 mg	$95.00
10mM * 1mL in DMSO	$55.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AZD-9291 (Osimertinib)

Liu YN, .et al. Acquired resistance to EGFR tyrosine kinase inhibitors is mediated by the reactivation of STC2/JUN/AXL signaling in lung cancer, Int J Cancer, 2019, Jun 4 PMID: 31162839

Biological Activity

AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors.

Targets

L858R/T790M EGFR (LoVo cells)	Exon 19 deletion EGFR (LoVo cells)	WT EGFR (LoVo cells)
11.44 nM	12.92 nM	493.8 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 90 mg/mL (180.14 mM)
	Water	Insoluble
	Ethanol	Warmed: 39 mg/mL (78.05 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	7.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.02 mL	100.08 mL	200.16 mL
0.5 mM	4 mL	20.02 mL	40.03 mL
1 mM	2 mL	10.01 mL	20.02 mL
5 mM	0.4 mL	2 mL	4 mL

*The above data is based on the productmolecular weight 499.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A13681
Actions	Inhibitor
CAS No.	1421373-65-0
Formula	C28H33N7O2
M. Wt	499.61
Purity	>98%
Synonyms	AZD 9291, AZD9291
SMILES	CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.