AZD2014 (Vistusertib)

AZD2014 (Vistusertib) Chemical Structure

CAS NO. 1009298-59-2

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.

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Package Price Qty
5 mg
$70.00
10 mg
$120.00
25 mg
$200.00
50 mg
$270.00
10mM * 1mL in DMSO
$55.00
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Biological Activity

AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor.
Targets
mTOR (Cell-free assay) P-Akt (S473) (Cell-free assay) pS6 (S235/236) (Cell-free assay)
2.8 nM80 nM200 nM
In vitro (25°C) DMSO 32 mg/mL (69.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.11 mL 216.22 mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11303
Actions Inhibitor
CAS No. 1009298-59-2
Formula C25H30N6O3
M. Wt 462.5
Purity >98%
Synonyms AZD-2014
SMILES C[[email protected]]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[[email protected]@H]5C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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