AZD2716 is a selective inhibitor of secretory phospholipase A2 (sPLA2), specifically targeting sPLA2-IIa, sPLA2-V, and sPLA2-X with IC50 values of 10 nM, 40 nM, and 400 nM, respectively. By effectively reducing pro-inflammatory lipid production, AZD2716 diminishes macrophage activation and foam cell formation. This compound is valuable for investigating the pathways involved in atherosclerosis and various inflammatory diseases linked to sPLA2 activity.
AZD2716 is a selective inhibitor of secretory phospholipase A2 (sPLA2), specifically targeting sPLA2-IIa, sPLA2-V, and sPLA2-X with IC50 values of 10 nM, 40 nM, and 400 nM, respectively. By effectively reducing pro-inflammatory lipid production, AZD2716 diminishes macrophage activation and foam cell formation. This compound is valuable for investigating the pathways involved in atherosclerosis and various inflammatory diseases linked to sPLA2 activity.
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