AZD3759

Catalog No.: A15551

EGFR inhibitor

AZD3759

AZD3759 Chemical Structure

CAS NO. 1626387-80-1

AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR.

Availability: In stock

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10 mg

Regular Price: $80.00

Special Price $64.00

25 mg

Regular Price: $120.00

Special Price $96.00

50 mg

Regular Price: $150.00

Special Price $120.00

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Biological Activity

AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR.
Targets
EGFR (L858R) EGFR (exon 19Del) EGFR (WT)
0.2 nM0.2 nM0.3 nM
In vitro DMSO 80 mg/mL (173.94 mM)
Water Insoluble
Ethanol Warmed: 18 mg/mL (39.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.74 mL 108.72 mL 217.44 mL
0.5 mM 4.35 mL 21.74 mL 43.49 mL
1 mM 2.17 mL 10.87 mL 21.74 mL
5 mM 0.43 mL 2.17 mL 4.35 mL

*The above data is based on the productmolecular weight 459.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15551
Actions Inhibitor
CAS No. 1626387-80-1
Formula C22H23ClFN5O3
M. Wt 459.9
Purity >98%
Synonyms AZD 3759
SMILES CC1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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