AZD5153 6-Hydroxy-2-naphthoic acid

Catalog No.: A21852

BET/BRD4 bromodomain inhibitor

AZD5153 6-Hydroxy-2-naphthoic acid

AZD5153 6-Hydroxy-2-naphthoic acid Chemical Structure

CAS NO. 1869912-40-2

AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.

Availability: In stock

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5 mg

Regular Price: $130.00

Special Price $104.00

10 mg

Regular Price: $223.00

Special Price $178.40

50 mg

Regular Price: $662.00

Special Price $529.60

100 mg

Regular Price: $1,325.00

Special Price $1,060.00

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Biological Activity

AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.
In vitro DMSO 93 mg/mL (139.27 mM)
Water Insoluble
Ethanol Warmed: 25 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.98 mL 74.88 mL 149.76 mL
0.5 mM 3 mL 14.98 mL 29.95 mL
1 mM 1.5 mL 7.49 mL 14.98 mL
5 mM 0.3 mL 1.5 mL 3 mL

*The above data is based on the productmolecular weight 667.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21852
Actions Inhibitor
CAS No. 1869912-40-2
Formula C36H41N7O6
M. Wt 667.75
Solubility DMSO
Purity >98%
Synonyms AZD-5153 HNT salt, AZD5153, AZD 5153
SMILES O=C(C1=CC=C2C=C(O)C=CC2=C1)O.O=C3N(C)CCN(CCOC4=CC=C(C5CCN(C6=NN7C(C=C6)=NN=C7OC)CC5)C=C4)[[email protected]@H]3C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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