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AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
Targets
| Target | Value |
|---|---|
| mTOR(truncated) | IC50: 0.13nM |
| mTOR(fulllength) | IC50: 0.8nM |
| DNA-PK | IC50: 1370nM |
| PI3Kδ | IC50: 3200nM |
| PI3Kα | IC50: 3590nM |
| ATM | IC50: 7350nM |
| PI3Kγ | IC50: >14790nM |
| PI3Kβ | IC50: 18900nM |
| In vitro | DMSO | 50 mg/mL heating (107.4 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 3 mg/mL (6.44 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.48 mL | 107.41 mL | 214.82 mL |
| 0.5 mM | 4.3 mL | 21.48 mL | 42.96 mL |
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10114 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 465.5 |
| Formula | C25H31N5O4 |
| Solubility | DMSO>93mg/mL Water>2mg/mL Ethanol>15mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1009298-09-2 |
| Synonyms | AZD-8055 |
| SMILES | C[[email protected]]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[[email protected]@H]5C |
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