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mTOR Inhibitor

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Catalog No. A10114

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD8055 10mg A10114-10

Regular Price: €38.00

Special Price: €34.20

AZD8055 25mg A10114-25

Regular Price: €76.00

Special Price: €68.40

AZD8055 50mg A10114-50

Regular Price: €114.00

Special Price: €102.60

AZD8055 100mg A10114-100

Regular Price: €171.00

Special Price: €153.90

AZD8055 10mM * 1mL in DMSO A10114-10mM-D

Regular Price: €74.10

Special Price: €66.69

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.


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Publications citing Adooq Products
AZD8055 Citations (2)
  • Helga Weber, .et al. Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice, Oncotarget, 2015, Oct 13; 6(31): 31877-31888 PMID: 26397134
  • Kentaro Hirose, .et al. Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins, BMC Dev Biol, 2014, 14: 42. PMID: 25480380

Chemical Information

Catalog Num A10114
Actions Inhibitor
M. Wt 465.5
Formula C25H31N5O4
Solubility DMSO>93mg/mL Water>2mg/mL Ethanol>15mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1009298-09-2
Synonyms AZD-8055
SMILES C[[email protected]]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=C(C=C4)OC)CO)N5CCOC[[email protected]@H]5C

Biological Activity

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
Target Value
mTOR(truncated)IC50: 0.13nM
mTOR(fulllength)IC50: 0.8nM
DNA-PKIC50: 1370nM
PI3KδIC50: 3200nM
PI3KαIC50: 3590nM
ATMIC50: 7350nM
PI3KγIC50: >14790nM
PI3KβIC50: 18900nM


Solubility (25°C)* In vitro DMSO 50 mg/mL heating (107.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (6.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.82mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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