AZD9362

Catalog No.: A33799
IGF-1R/InsR Inhibitor
AZD9362 is a reversible, ATP-competitive inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR). It exhibits potent biological activity with an IC50 of 14 nM for IGF-1R inhibition, making it suitable for cancer research applications. This compound has been shown to enhance the anti-tumor efficacy of AZD5363, presenting significant potential in the study of various cancers, including breast cancer.
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5mg
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50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAZD9362 is a reversible, ATP-competitive inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR). It exhibits potent biological activity with an IC50 of 14 nM for IGF-1R inhibition, making it suitable for cancer research applications. This compound has been shown to enhance the anti-tumor efficacy of AZD5363, presenting significant potential in the study of various cancers, including breast cancer.
Product Information
Catalog NumA33799
FormulaC24H27ClN8O2
Molecular Weight494.98
CAS Number1905412-80-7
SMILESCC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C(C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
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