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Azemiopsin

Catalog No.: A67642
nAChR Inhibitor
Azemiopsin is a potent inhibitor of nicotinic acetylcholine receptors (nAChR), exhibiting IC50 values of 0.18 μM against the T. californica nAChR and 22 μM against the human α7 nAChR. This compound effectively blocks acetylcholine-induced currents in Xenopus oocytes that are heterologously expressing human muscle-type nAChR. Azemiopsin serves as a valuable tool for investigating nAChR-mediated signaling pathways and contributes to studies on neuropharmacology and synaptic transmission.
Azemiopsin 1391936-86-9 nAChR Inhibitor
Grouped product items
Size Price Stock Qty
5mg
$95.00
In stock
10mg
$155.00
In stock
25mg
$260.00
In stock
50mg
$410.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAzemiopsin is a potent inhibitor of nicotinic acetylcholine receptors (nAChR), exhibiting IC50 values of 0.18 μM against the T. californica nAChR and 22 μM against the human α7 nAChR. This compound effectively blocks acetylcholine-induced currents in Xenopus oocytes that are heterologously expressing human muscle-type nAChR. Azemiopsin serves as a valuable tool for investigating nAChR-mediated signaling pathways and contributes to studies on neuropharmacology and synaptic transmission.
Product Information
Catalog NumA67642
FormulaC118H174N38O26
Molecular Weight2540.88
CAS Number1391936-86-9
SequenceAsp-Asn-Trp-Trp-Pro-Lys-Pro-Pro-His-Gln-Gly-Pro-Arg-Pro-Pro-Arg-Pro-Arg-Pro-Lys-Pro
Sequence shorteningDNWWPKPPHQGPRPPRPRPKP
SMILESC([C@@H](C(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(=O)N3[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(NCC(=O)N5[C@H](C(N[C@H](C(=O)N6[C@H](C(=O)N7[C@H](C(N[C@H](C(=O)N8[C@H](C(N[C@H](C(=O)N9[C@H](C(N[C@H](C(=O)N%10[C@H](C(O)=O)CCC%10)CCCCN)=O)CCC9)CCCNC(=N)N)=O)CCC8)CCCNC(=N)N)=O)CCC7)CCC6)CCCNC(=N)N)=O)CCC5)=O)CCC(N)=O)=O)=O)CCC3)CCC2)CCCCN)=O)CCC1)NC([C@H](CC=%11C=%12C(NC%11)=CC=CC%12)NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(N)=O)=O)=O)C=%13C=%14C(NC%13)=CC=CC%14
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Neuronal Signaling > nAChR