Azido-PEG2-VHL is a multikinase degrader that serves as a versatile building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-functionalized molecules, such as those containing DBCO or BCN groups. Its application in targeted protein degradation makes it a valuable tool in chemical biology research.
Azido-PEG2-VHL is a multikinase degrader that serves as a versatile building block for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-functionalized molecules, such as those containing DBCO or BCN groups. Its application in targeted protein degradation makes it a valuable tool in chemical biology research.
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