Azido-PEG8-Amido-Val-Cit-PAB is a cleavable linker designed for antibody-drug conjugates (ADCs), targeting Cathepsin B for selective payload release within lysosomes. The Val-Cit moiety ensures that drug release occurs specifically in the intracellular environment, enhancing therapeutic efficacy while minimizing systemic toxicity. The azido group allows for efficient conjugation to DBCO, BCN, or other alkyne-containing molecules through click chemistry. The polyethylene glycol (PEG) spacer improves aqueous solubility, making this reagent suitable for various research applications in drug development.
Azido-PEG8-Amido-Val-Cit-PAB is a cleavable linker designed for antibody-drug conjugates (ADCs), targeting Cathepsin B for selective payload release within lysosomes. The Val-Cit moiety ensures that drug release occurs specifically in the intracellular environment, enhancing therapeutic efficacy while minimizing systemic toxicity. The azido group allows for efficient conjugation to DBCO, BCN, or other alkyne-containing molecules through click chemistry. The polyethylene glycol (PEG) spacer improves aqueous solubility, making this reagent suitable for various research applications in drug development.
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