β-Funaltrexamine (β-FNA) is an irreversible and selective antagonist of the μ-opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by modulating TLR4 signaling, inhibiting cytokine-induced iNOS activation, and reducing neuroinflammation. Additionally, β-FNA influences NF-κB signaling and chemokine expression in human astrocytes and murine models. It is an important tool for research into neurodegenerative diseases, including stroke.
β-Funaltrexamine (β-FNA) is an irreversible and selective antagonist of the μ-opioid receptor. This compound demonstrates significant anti-inflammatory and neuroprotective properties by modulating TLR4 signaling, inhibiting cytokine-induced iNOS activation, and reducing neuroinflammation. Additionally, β-FNA influences NF-κB signaling and chemokine expression in human astrocytes and murine models. It is an important tool for research into neurodegenerative diseases, including stroke.
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