β-Glu-PAB(CH2NH2)-Exatecan is a selective inhibitor of topoisomerase I. It disrupts the topoisomerase I-DNA complex, preventing DNA strand rejoining, which leads to DNA breakage and subsequent apoptosis in cancer cells. This compound is specifically designed to be activated by β-glucuronidase, which is highly expressed in the tumor microenvironment, thereby activating Exatecan and enhancing its cytotoxicity. β-Glu-PAB(CH2NH2)-Exatecan serves as a valuable tool for cancer research, particularly in exploring targeted therapies.
β-Glu-PAB(CH2NH2)-Exatecan is a selective inhibitor of topoisomerase I. It disrupts the topoisomerase I-DNA complex, preventing DNA strand rejoining, which leads to DNA breakage and subsequent apoptosis in cancer cells. This compound is specifically designed to be activated by β-glucuronidase, which is highly expressed in the tumor microenvironment, thereby activating Exatecan and enhancing its cytotoxicity. β-Glu-PAB(CH2NH2)-Exatecan serves as a valuable tool for cancer research, particularly in exploring targeted therapies.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
