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Bafetinib (INNO-406)


Bcr-Abl inhibitor

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Catalog No. A10119

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Bafetinib 5mg A10119-5

Regular Price: €71.25

Special Price: €64.13

Bafetinib 10mg A10119-10

Regular Price: €123.50

Special Price: €111.15

Bafetinib 50mg A10119-50

Regular Price: €370.50

Special Price: €333.45

Bafetinib 100mg A10119-100

Regular Price: €456.00

Special Price: €410.40

Bafetinib (INNO-406) 10mM * 1mL in DMSO A10119-10mM-D

Regular Price: €165.30

Special Price: €148.77

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.

Bafetinib (INNO-406)

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Publications citing Adooq Products
Bafetinib (INNO-406) Citations (4)
  • Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • S. Dallari, .et al. Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses, Nat Commun, 2017, 8: 14830 PMID: 28368000
  • Andrea Haerzschel, .et al. BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia, Ann Hematol, 2016, 95(12): 1979-1988 PMID: 27542958
  • Magdalena Winiarska, .et al. Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies, MAbs., 2014, 6(5): 1300-1313. PMID: 25517315

Chemical Information

Catalog Num A10119
Actions Inhibitor
M. Wt 576.6
Formula C30H31F3N8O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 859212-16-1
Synonyms NS-187
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[[email protected]@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5

Biological Activity

Bafetinib ((INNO-406) is a dual Bcr-Abl/Lyn tyrosine kinase inhibitor for the potential treatment of leukemia.
Abl (Cell-free assay) Lyn (Cell-free assay)
5.8 nM19 nM


Solubility (25°C) * In vitro DMSO 100 mg/mL (173.42 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.34 mL 86.72 mL 173.43mL
0.5 mM 3.47 mL 17.34 mL 34.69 mL
1 mM 1.73 mL 8.67 mL 17.34 mL
5 mM 0.35 mL 1.73 mL 3.47 mL

*The above data is based on the productmolecular weight 576.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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