BC-1901S is a proteasome-independent activator and stabilizer of NRF2. It functions by binding to DCAF1, an E3 ligase subunit, disrupting the NRF2/DCAF1 interaction, and inhibiting NRF2 ubiquitination through a KEAP1-independent pathway. BC-1901S demonstrates anti-inflammatory effects in murine models of LPS-induced acute lung injury, making it a valuable tool for research into NRF2-related pathways and inflammation.
BC-1901S is a proteasome-independent activator and stabilizer of NRF2. It functions by binding to DCAF1, an E3 ligase subunit, disrupting the NRF2/DCAF1 interaction, and inhibiting NRF2 ubiquitination through a KEAP1-independent pathway. BC-1901S demonstrates anti-inflammatory effects in murine models of LPS-induced acute lung injury, making it a valuable tool for research into NRF2-related pathways and inflammation.
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