BD-1008 dihydrobromide is a nonselective σ receptor antagonist, exhibiting Ki values of 2 nM for the σ1 receptor and 8 nM for the σ2 receptor. It demonstrates minimal affinity for the D2 receptor (Ki = 1112 nM) and very low affinity for the dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide effectively antagonizes dopamine release in the shell region of the nucleus accumbens via σ₂ receptor inhibition and interferes with the self-administration of σ agonists. This compound is valuable for research in addiction therapy targeting σ receptors.
BD-1008 dihydrobromide is a nonselective σ receptor antagonist, exhibiting Ki values of 2 nM for the σ1 receptor and 8 nM for the σ2 receptor. It demonstrates minimal affinity for the D2 receptor (Ki = 1112 nM) and very low affinity for the dopamine transporter (DAT) (Ki > 10,000 nM). BD-1008 dihydrobromide effectively antagonizes dopamine release in the shell region of the nucleus accumbens via σ₂ receptor inhibition and interferes with the self-administration of σ agonists. This compound is valuable for research in addiction therapy targeting σ receptors.
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