BD-1008 is a potent nonselective σ receptor antagonist, exhibiting Ki values of 2 nM and 8 nM for σ1 and σ2 receptors, respectively. With minimal affinity for the D2 receptor (Ki = 1112 nM) and negligible binding to the dopamine transporter (Ki > 10,000 nM), BD-1008 effectively antagonizes dopamine release in the nucleus accumbens shell region through σ₂ receptor blockade. This compound serves as a valuable tool for investigating addiction therapies targeting σ receptors.
BD-1008 is a potent nonselective σ receptor antagonist, exhibiting Ki values of 2 nM and 8 nM for σ1 and σ2 receptors, respectively. With minimal affinity for the D2 receptor (Ki = 1112 nM) and negligible binding to the dopamine transporter (Ki > 10,000 nM), BD-1008 effectively antagonizes dopamine release in the nucleus accumbens shell region through σ₂ receptor blockade. This compound serves as a valuable tool for investigating addiction therapies targeting σ receptors.
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