BE-10988 is a potent DNA topoisomerase inhibitor that disrupts the normal function of this enzyme, leading to the formation of stabilized enzyme-DNA complexes. This compound effectively inhibits the growth of Doxorubicin- and vincristine-resistant P388 mouse leukemia cell lines, indicating its potential utility in overcoming drug resistance in cancer treatment. BE-10988 offers valuable insights for research in cancer biology and therapeutic development.
BE-10988 is a potent DNA topoisomerase inhibitor that disrupts the normal function of this enzyme, leading to the formation of stabilized enzyme-DNA complexes. This compound effectively inhibits the growth of Doxorubicin- and vincristine-resistant P388 mouse leukemia cell lines, indicating its potential utility in overcoming drug resistance in cancer treatment. BE-10988 offers valuable insights for research in cancer biology and therapeutic development.
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