BE2012 is a potent and selective antagonist of REV-ERBα and REV-ERBβ, exhibiting EC50 values of 0.285 μM and 0.346 μM, respectively. By binding to the ligand-binding domain of REV-ERB, BE2012 inhibits the recruitment of co-inhibitory factors, leading to the release of transcriptional repression on downstream target genes. This compound has been demonstrated to upregulate myogenic transcription factors, such as Myf5 and Myod, and is applicable in research focused on muscle regeneration and repair in models of acute muscle injury.
BE2012 is a potent and selective antagonist of REV-ERBα and REV-ERBβ, exhibiting EC50 values of 0.285 μM and 0.346 μM, respectively. By binding to the ligand-binding domain of REV-ERB, BE2012 inhibits the recruitment of co-inhibitory factors, leading to the release of transcriptional repression on downstream target genes. This compound has been demonstrated to upregulate myogenic transcription factors, such as Myf5 and Myod, and is applicable in research focused on muscle regeneration and repair in models of acute muscle injury.
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