Benzamil hydrochloride is a selective blocker of the epithelial sodium channel (ENaC) and serves as an inhibitor of the Na+/Ca2+ exchanger (NCX) with an IC50 of approximately 100 nM. This compound also enhances myogenic vasoconstriction and inhibits TRPP3-mediated Ca2+-activated currents at an IC50 of 1.1 μM. Benzamil hydrochloride is employed in various research applications aimed at studying ion channel regulation and cardiovascular physiology.
Benzamil hydrochloride is a selective blocker of the epithelial sodium channel (ENaC) and serves as an inhibitor of the Na+/Ca2+ exchanger (NCX) with an IC50 of approximately 100 nM. This compound also enhances myogenic vasoconstriction and inhibits TRPP3-mediated Ca2+-activated currents at an IC50 of 1.1 μM. Benzamil hydrochloride is employed in various research applications aimed at studying ion channel regulation and cardiovascular physiology.
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