BI 186908 is a selective and orally active antagonist of the melanin-concentrating hormone (MCH) receptor 1, demonstrating an IC50 of 22 nM and a Ki of 14 nM. This compound exhibits high affinity for recombinant MCH-R1 across several species, including human, cynomolgus monkey, dog, and rat, with IC50 values ranging from 18 nM to 23 nM. BI 186908 has been shown to significantly reduce body weight in diet-induced obese rat models, making it a valuable tool for research in obesity and related metabolic disorders.
BI 186908 is a selective and orally active antagonist of the melanin-concentrating hormone (MCH) receptor 1, demonstrating an IC50 of 22 nM and a Ki of 14 nM. This compound exhibits high affinity for recombinant MCH-R1 across several species, including human, cynomolgus monkey, dog, and rat, with IC50 values ranging from 18 nM to 23 nM. BI 186908 has been shown to significantly reduce body weight in diet-induced obese rat models, making it a valuable tool for research in obesity and related metabolic disorders.
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