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- Mi Chen, .et al. TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation, EMBO Rep, 2022, Aug 3;23(8):e53468 PMID: 35785414
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Anowara Khatun, .et al. Transcriptional Repression and Protein Degradation of the Ca2+-Activated K+ Channel KCa1.1 by Androgen Receptor Inhibition in Human Breast Cancer Cells, Front Physiol, 2018, 9: 312 PMID: 29713287
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
Biological Activity
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism.
Targets
| Androgen Receptor (LNCaP/AR(cs) cells) | ||||
| 0.16 μM |
| In vitro | DMSO | 84 mg/mL (195.17 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (11.61 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.23 mL | 116.17 mL | 232.34 mL |
| 0.5 mM | 4.65 mL | 23.23 mL | 46.47 mL |
| 1 mM | 2.32 mL | 11.62 mL | 23.23 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.65 mL |
*The above data is based on the productmolecular weight 430.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10142 |
|---|---|
| Actions | Antagonist |
| CAS No. | 90357-06-5 |
| Formula | C18H14F4N2O4S |
| M. Wt | 430.4 |
| Purity | >98% |
| Synonyms | Cosudex, Calutide, Kalumid |
| SMILES | CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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Email: [email protected]
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