(+)-Bicuculline methochloride is a potent antagonist of the GABAA receptor, modulating inhibitory neurotransmission in the central nervous system. This compound alters neuronal membrane properties and firing patterns, leading to a reduction in Apamin-sensitive afterhyperpolarization. By inhibiting apamin-sensitive Ca2+-activated K+ currents, (+)-Bicuculline methochloride enhances burst firing, making it a valuable tool for studying synaptic transmission and neuronal excitability in various research applications.
(+)-Bicuculline methochloride is a potent antagonist of the GABAA receptor, modulating inhibitory neurotransmission in the central nervous system. This compound alters neuronal membrane properties and firing patterns, leading to a reduction in Apamin-sensitive afterhyperpolarization. By inhibiting apamin-sensitive Ca2+-activated K+ currents, (+)-Bicuculline methochloride enhances burst firing, making it a valuable tool for studying synaptic transmission and neuronal excitability in various research applications.
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