BIIB021

Catalog No.: A10143

HSP90 inhibitor

BIIB021

BIIB021 Chemical Structure

CAS NO. 848695-25-0

BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$80.00
50 mg
$210.00
100 mg
$320.00
10mM * 1mL in DMSO
$60.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107-113

Biological Activity

BIIB021 is an oral fully synthetic Hsp90 inhibitor that selectively and potently inhibits the molecular chaperone Hsp90 thereby inhibiting the proper assembly of multiple oncogenic proteins involved in tumor growth and survival.
Targets
HSP90 HSP90
1.7 nM(Ki)38 nM(EC50)
In vitro (25°C) DMSO 60 mg/mL (188.22 mM)
Water Insoluble
Ethanol 2 mg/mL (6.27 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.37 mL 156.84 mL 313.68 mL
0.5 mM 6.27 mL 31.37 mL 62.74 mL
1 mM 3.14 mL 15.68 mL 31.37 mL
5 mM 0.63 mL 3.14 mL 6.27 mL

*The above data is based on the productmolecular weight 318.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10143
Actions Inhibitor
CAS No. 848695-25-0
Formula C14H15ClN6O
M. Wt 318.8
Purity >98%
Synonyms CNF2024
SMILES CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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