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Bimokalner

Catalog No.: A68091
Kv7.4 Agonist
Bimokalner is a selective agonist of the voltage-gated potassium channel Kv7.4. It is known to enhance Kv7.4 channel activity, leading to hyperpolarization of neuronal membranes and potential modulation of neuronal excitability. This compound is valuable in research focused on neurophysiology, cardiovascular function, and the pharmacological modulation of ion channels.
Bimokalner 2243284-19-5 Kv7.4 Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBimokalner is a selective agonist of the voltage-gated potassium channel Kv7.4. It is known to enhance Kv7.4 channel activity, leading to hyperpolarization of neuronal membranes and potential modulation of neuronal excitability. This compound is valuable in research focused on neurophysiology, cardiovascular function, and the pharmacological modulation of ion channels.
Product Information
Catalog NumA68091
FormulaC15H18F5NOS
Molecular Weight355.37
CAS Number2243284-19-5
SMILESFS(F)(F)(F)(F)C1=CC=CC(CNC([C@@H]2[C@]3([H])C[C@](CC3)([H])C2)=O)=C1
SynonymsBimokalnerum
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Membrane Transporters-Ion Channels > Potassium Channels