Birinapant (TL32711)

Name: Birinapant (TL32711)
Brand: Adooq Bioscience
SKU: A12738
Rating: 100 (268 reviews)

Catalog No.: A12738

XIAP/cIAP1 antagonist

Birinapant (TL32711) Chemical Structure

CAS NO. 1260251-31-7

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
25 mg	$200.00
50 mg	$280.00
10mM * 1mL in DMSO	$100.00
Custom Size	Get quote

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Biological Activity

Targets

cIAP1 (Cell-free assay)	XIAP (Cell-free assay)
<1 nM(Kd)	45 nM(Kd)

Solubility *

In vitro	DMSO	87 mg/mL (107.81 mM)
	Water	Insoluble
	Ethanol	48 mg/mL (59.48 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.39 mL	61.96 mL	123.92 mL
0.5 mM	2.48 mL	12.39 mL	24.78 mL
1 mM	1.24 mL	6.2 mL	12.39 mL
5 mM	0.25 mL	1.24 mL	2.48 mL

*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12738
Actions	Antagonist
CAS No.	1260251-31-7
Formula	C42H56F2N8O6
M. Wt	806.94
Purity	>98%
Synonyms	TL-32711, TL 32711
SMILES	CC[[email protected]@H](C(=O)N1C[[email protected]](C[[email protected]]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[[email protected]@H]6C[[email protected]@H](CN6C(=O)[[email protected]](CC)NC(=O)[[email protected]](C)NC)O)O)NC(=O)[[email protected]](C)NC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.