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Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
Targets
| cIAP1 (Cell-free assay) | XIAP (Cell-free assay) | |||
| <1 nM(Kd) | 45 nM(Kd) |
| In vitro (25°C) | DMSO | 100 mg/mL (123.92 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 55 mg/mL (68.15 mM) | ||
| In vivo | 15% Captisol | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.39 mL | 61.96 mL | 123.92 mL |
| 0.5 mM | 2.48 mL | 12.39 mL | 24.78 mL |
| 1 mM | 1.24 mL | 6.2 mL | 12.39 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.48 mL |
*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A12738 |
|---|---|
| Actions | Antagonist |
| M. Wt | 806.94 |
| Formula | C42H56F2N8O6 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1260251-31-7 |
| Synonyms | TL-32711, TL 32711 |
| SMILES | CC[[email protected]@H](C(=O)N1C[[email protected]](C[[email protected]]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[[email protected]@H]6C[[email protected]@H](CN6C(=O)[[email protected]](CC)NC(=O)[[email protected]](C)NC)O)O)NC(=O)[[email protected]](C)NC |
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