Birinapant (TL32711)

Catalog No.: A12738

XIAP/cIAP1 antagonist

Birinapant (TL32711)

Birinapant (TL32711) Chemical Structure

CAS NO. 1260251-31-7

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $70.00

Special Price $56.00

10 mg

Regular Price: $120.00

Special Price $96.00

25 mg

Regular Price: $200.00

Special Price $160.00

50 mg

Regular Price: $280.00

Special Price $224.00

10mM * 1mL in DMSO
$100.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity.
Targets
cIAP1 (Cell-free assay) XIAP (Cell-free assay)
<1 nM(Kd)45 nM(Kd)
In vitro (25°C) DMSO 100 mg/mL (123.92 mM)
Water <1 mg/mL (<1 mM)
Ethanol 55 mg/mL (68.15 mM)
In vivo 15% Captisol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.39 mL 61.96 mL 123.92 mL
0.5 mM 2.48 mL 12.39 mL 24.78 mL
1 mM 1.24 mL 6.2 mL 12.39 mL
5 mM 0.25 mL 1.24 mL 2.48 mL

*The above data is based on the productmolecular weight 806.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A12738
Actions Antagonist
M. Wt 806.94
Formula C42H56F2N8O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1260251-31-7
Synonyms TL-32711, TL 32711
SMILES CC[[email protected]@H](C(=O)N1C[[email protected]](C[[email protected]]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[[email protected]@H]6C[[email protected]@H](CN6C(=O)[[email protected]](CC)NC(=O)[[email protected]](C)NC)O)O)NC(=O)[[email protected]](C)NC

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