BMS-214662 hydrochloride is a potent farnesyltransferase inhibitor that disrupts the prenylation of Ras proteins, preventing their localization and function at the cell membrane. This inhibition leads to significant anti-tumor activity, making it a valuable tool for cancer research. The compound demonstrates a high affinity for H-Ras with an IC50 of 1.3 nM and for K-Ras with an IC50 of 8.4 nM, highlighting its potential in studying tumorigenesis associated with Ras signaling pathways.
BMS-214662 hydrochloride is a potent farnesyltransferase inhibitor that disrupts the prenylation of Ras proteins, preventing their localization and function at the cell membrane. This inhibition leads to significant anti-tumor activity, making it a valuable tool for cancer research. The compound demonstrates a high affinity for H-Ras with an IC50 of 1.3 nM and for K-Ras with an IC50 of 8.4 nM, highlighting its potential in studying tumorigenesis associated with Ras signaling pathways.
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