BMS-250749 is a potent inhibitor of topoisomerase I (Top I) derived from the fluoroglycosyl-3,9-difluoroindolecarbazole class. It demonstrates significant cytotoxic effects and selectivity, exhibiting notable antitumor activity in Lewis lung cancer models. Additionally, BMS-250749 has shown broad-spectrum antitumor efficacy, outperforming CPT-11 in select preclinical xenograft studies.
BMS-250749 is a potent inhibitor of topoisomerase I (Top I) derived from the fluoroglycosyl-3,9-difluoroindolecarbazole class. It demonstrates significant cytotoxic effects and selectivity, exhibiting notable antitumor activity in Lewis lung cancer models. Additionally, BMS-250749 has shown broad-spectrum antitumor efficacy, outperforming CPT-11 in select preclinical xenograft studies.
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